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ARPN Journal of Science and Technology >> Volume 7, Issue 1, January 2017

ARPN Journal of Science and Technology


Mini Review Telomerase-A Biomarker in the Carcinogenesis and Diagnosis.

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Author Malti Narwaria, Archana Shrivastav, B.R. Shrivastav
ISSN 2225-7217
On Pages 733-737
Volume No. 2
Issue No. 8
Issue Date October 01, 2012
Publishing Date October 01, 2012
Keywords Telomerase, Immortality, Euplastic.



Abstract

Telomerase is an attractive cancer target as appear to be required in essentially all tumors for immortalization of a subset of cells, including cancer stem cells. Moreover differences in telomerase expression and telomere length between normal and tumor tissues suggest that targeting telomerase would relatively safe. In normal adults, telomerase activation mainly presents in tissue stem cells and progenitor cells giving them unlimited growth potential. Cells immortalized in vitro, on the other hand, express telomerase and maintain their telomeres. Telomerase activity has also been detected in the large majority of tumors from a variety of cancers [1]. Telomerase expression is a potentially important marker of high-grade cervical dysplasia and squamous cell carcinoma (SCC).Ectopic expression of telomerase reverse transcriptase (TERT), the protein catalytic subunit of telomerase, can reconstitute telomerase activity, lengthen telomeres, and bypass both senescence and crisis, endowing human fibroblasts with immortal proliferative properties. Telomerase is a fundamental marker of euplastic transformation that is widely expressed in both premalignant intraepithelial lesions and in most malignant lesions of the uterine cervix [41], and therefore, is a potential element in the carcinogenesis and diagnosis.


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