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ARPN Journal of Science and Technology >> Volume 7, Issue 1, January 2017

ARPN Journal of Science and Technology


Lipid Profile of Alloxan-Induced Diabetic Albino Wistar Rats Treated with Ethanol Whole Extract and Fractions of Nauclea Latifolia Leaves

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Author Asanga Edet, Patrick Ebong , Olorunfemi Eseyin, , Imaobong Udoh, Robert Eyo, Grace Effiong
ISSN 2225-7217
On Pages 1009-1013
Volume No. 3
Issue No. 10
Issue Date November 01, 2013
Publishing Date November 01, 2013
Keywords Nauclea latifolium, lipid profile, diabetes mellitus, photochemistry



Abstract

The ethanol extract and its fractions were evaluated in the study to unravel their effects on the lipid profile of diabetic rats after daily administration for a period of two weeks. The analysis of the results showed that there were significant decreases (p < 0.05) in the HDL-cholesterol and total cholesterol levels in all the treatment groups. Insignificant decreases (p > 0.05) in TG levels were recorded in all the treatment groups where as VLDL-C levels significantly decreased (p < 0.05) in the groups treated with glibenclamide, methanol fraction (100 mg/kg) as well as butanol and ethyl acetate fractions. The result of the phytochemical screening showed heavy presence of saponins, flavonoids, phenols, terpenoids, cardiac glycosides and carbohydrates in ethyl acetate, butanol and methanol fractions which may be the reason for the hypolipidaemic property of the above fractions and suggest its potency in arresting oxidative stress in diabetic rats. Also, the n-hexane and ethyl acetate fractions as well as ethanol extract gave hope in arresting hyperlipidemia resulting from diabetes mellitus in diabetic rats.


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