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ARPN Journal of Science and Technology >> Volume 7, Issue 1, January 2017

ARPN Journal of Science and Technology


Anti-diabetic and Anti-hyperlipedemic Properties of Ethanolic Root Extract of Gongronema Latifolium (Utazi) on Streptozotocin (STZ) Induced Diabetic Rats

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Author A. E. Robert, U. O. Luke, E. O. Udosen, S.U. Ufot, A E Effiong, V.S. Ekam
ISSN 2225-7217
On Pages 995-998
Volume No. 3
Issue No. 10
Issue Date November 01, 2013
Publishing Date November 01, 2013
Keywords Diabetes mellitus, streptozotocin, ant diabetic, antihyperlipidemic



Abstract

Diabetes mellitus is associated with alteration in carbohydrate and lipid metabolism. The present study was designed to investigate the hypoglycaemic and hypolipedemic activities of ethanolic root extract of Gongronema latifolium (GL) in Streptozotocin (STZ) diabetic rats. Diabetes was induced by intraperitoneal injection of STZ (65mg/kg b.w) after a 24hour fast. After being confirmed as diabetic, the animals were treated with 200mg/kg b.w and 400mg/kg b.w of ethanolic root extract of GL for 14days. Induction of diabetes with STZ in experimental rats showed significant (P<0.05) increase in serum glucose, triacylglycerol (TG), total cholesterol (TC), very low density lipoprotein (VLDL) and significant (P<0.05) reduction in high density lipoprotein cholesterol (HDL-C) in the diabetic control group compared with the normal control. Treatment with extract (at these doses) significantly (p<0.05) reduced serum glucose, TG, TC, VLDL but increased HDL in diabetic rats. There was no significant change on low density lipoprotein (LDL) in serum. The result from this study suggests that root extract of GL has ant diabetic and hypolipidemic properties in experimental diabetes mellitus rats model and therefore could be used for the management of diabetes mellitus (DM) in human.


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